Bovine herpesvirus-1, or BHV-1 infects cattle. The virus can suppresses the animals' immune system, rendering them susceptible to other infections. Mannheimia haemolytica (M.h.) is a gram-negative bacteria that normally lives in the upper respiratory tract of cattle. However, when the immune system is depressed by viral infection, M.h. is able to colonize the lower respiratory tract and become virulent. The combination of pathogens leads to disease known as Bovine Respiratory Disease Complex and costs the cattle industry billion-dollar yearly losses. The goal of Russ' study is to determine how BHV-1 and M.h. might affect each other's gene expression. In this experiment, she uses Bovine Turbinate cells derived from the upper respiratory tract for an in vitro infection with BHV-1 and M.h. In the experiment, she uses 4 different conditions to test whether BHV-1 and M.h. cross-talk during infection. This research will help researchers to better understand the Bovine Respiratory Disease. Russ is a senior biochemistry major under the direction of Dr. Florencia Meyer, assistant professor in the Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology.
The College of Agriculture and Life Sciences Undergraduate Research Scholars program is an immersive experience designed to engage undergraduate scholars in research and creative activities beyond the traditional undergraduate curriculum. In this 12-month experience undergraduate students will work as a junior colleague within a faculty scholar/mentor's research program to discover new knowledge, enhance their discipline-specific expertise, and gain critical thinking skills. Learn More